Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling
Figure 6
The Pre-AHCT Donor Gene Expression Profile Correlates with the Recipient Expression Profile Examined One Year Post-AHCT
The Pearson correlation coefficient (rho) over the expression vectors of 711 informative genes (listed in Table S3) was calculated between members of all matching donor–recipient pairs, and all donor–donor and recipient–recipient pairs, and then averaged for each group. Bar graphs show the mean Pearson correlation coefficient between individual donors on day 0 with their recipient on day 365 (t0i − t3i) (red bar), between individual donors and all other donors on day 0 (t0i − t0) (yellow bar), and between individual recipients and all other recipients on day 365 (t3i − t3) (blue bar). Data are from all (40) donor–recipient pairs (A), or from pairs in which the recipient presented cGVHD (B), or not (C). Error bars represent the standard error of the mean. The vector of (t0i − t3i) correlations was compared to the vectors of (t0i − t0) and (t3i − t3) correlations using Student's t-test, to determine whether the differences between these observed sample pair correlation groups are statistically significant. t-Test p-values relative to (t0i − t3i) are labeled as follows: *, 0.01 < p < 0.05; **, 0.001 < p < 0.01; ***, p < 10−6.