Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor
Fig 5
Overexpression of c-Myc enhanced resistance of C4-2 MDV3100r cells against GRT treatment.
(A) Overexpression of c-Myc in LNCaP C4-2 MDV3100r cells was confirmed by Western blotting. (B) LNCaP C4-2 3100r cells with mock vector or c-Myc overexpression were treated with increasing concentration of GRT (0, 10, 25, 50, 75, 100 μg/ml) and cell proliferation was examined by proliferation assay. Asterisk ** and *** represents statistically significant difference p < 0.01 and p < 0.001, respectively, between the group as compared to control group or the denoted two groups being compared.