Standardized guinea pig model for Q fever vaccine reactogenicity
Fig 5
Zone of erythema at D42 intradermal challenge sites.
Data are shown as the zone of erythema (mm) at intradermal vaccine injection sites challenged at day 42 p.i., grouped by route of sensitization with C. burnetii Nine Mile (Cb9M) (i.p., intraperitoneal; i.n., intranasal) or saline controls. Measurements are presented for terminally harvested injection sites at day 7 p.c. (open shapes) and day 21 p.c. (filled shapes). Values are presented by challenge dose (A) 0 μg Coxevac, (B) 1 μg Coxevac, (C) 2 μg Coxevac, and (D) 4 μg Coxevac. 1Histopathological scoring (0–5) is as noted in Table 1. Error bars represent group mean and standard deviations. Group mean differences assessed by one-way ANOVA with Tukey’s multiple correction test; *P≤0.05.