Granulocyte Colony-Stimulating Factor Reduces Fibrosis in a Mouse Model of Chronic Pancreatitis
Figure 5
Semi-quantification of pancreatic collagen I, MMP-9 and MMP-13 by Western blot analysis.
(A) The Western blot analysis of collagen I, MMP-9 and MMP-13 expression in the pancreas of control mice and cerulein-treated mice with or without G-CSF sacrificed at week 7 and week 9. (B) The relative amount of pancreatic collagen I. Values are mean ± SD (n = 3–6). This result reveals that the relative amount of collagen I is significantly decreased in cerulein- and G-CSF treated mice sacrificed at week 9. (C) The relative amount of pancreatic MMP-9. Values are mean ± SD (n = 3–6). This result reveals that no significant change of MMP-9 was caused by G-CSF treatment in cerulein-treated mice sacrificed at week 7 and week 9. (D) The relative amount of pancreatic MMP-13. Values are mean ± SD (n = 3–6). This result reveals that no significant change of MMP-13 was caused by G-CSF treatment in cerulein-treated mice sacrificed at week 7 and week 9.