Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus
Fig 5
Neutralizing antibody levels induced by ZIKV VLP vaccination correlates with protection.
(5A) Comparison of Day 42 RlucNT50 titers in mice that survived (Protected) or died (Not Protected) after lethal ZIKV challenge. GMTs is shown by bars, individual titers by symbols, and assay LOD by dashed line. Significance value shown is from Mann-Whitney U test. (5B) Correlation of Day 49 (day 5 post-challenge) relative ZIKV GE compared to Day 42 RlucNT50 titers for all groups. (5C) Correlation of Day 49 (day 5 post-challenge) relative ZIKV GE compared to Day 42 RlucNT50 titers for the VLP 0.1μg dose group only. Log-transformed values for each serum RlucNT50 titer and Relative GE RNAemia load (symbols based on immunization group), with dashed lines representing the assay LOD for RlucNT50 assay (x-axis) or reference level for maximum naïve mouse Relative ZIKV GE as in Fig 4 (y-axis) are provided. R and P values as well as regression lines shown were determined by least squares regression analyses.