Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development
Figure 5
Survival Analyses of Human Lung AD Subclasses from Bhattacharjee et al. [ 10] Based on Lung Developmental Association
(A) AD samples identified as forming two distinct subclasses C2 and C4 by Bhattacharjee et al. seen from the genomic PC1 and PC3 perspective of the 472-gene mouse lung development framework. Each sample point is color-coded by its survival time. Circles indicate members of class C4, diamonds indicate members of class C2, and “X”s correspond to all other AD samples.
(B) Same as in (A), except that here only the stage I AD samples (such samples within C2, C4, and other) are highlighted. The mouse genomic PC1 halfway separation value between the C2 and C4 samples is noted.
(C) K-M plot based on 64 stage I AD patients separated into two groups by the mouse PC1 halfway separation value from (B) ( p = 0.0169); the low-survival group has 13 patients and the high-survival group has 51 patients.