Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival
Fig 5
Sphk1 activity and S1P analysis in palmitate and LPS treated RAW264.7 cells.
A. Sphk1 activity and B. S1P analysis normalized to respective controls. C. Fold change (log2) values of (G)SL analyzed in Raw264.7 challenged with BSA vs 500 μM BSA coupled to Palmitate (BSA-PA). The red color represents high-normalized levels and the blue color represents low levels of the lipids. (n = 3). Significance is evaluated by a student's t-test and indicated as * p < 0.05; ** p < 0.01 and ** p < 0.001.