Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility
Fig 5
(+)-Usnic acid decreases mRNA level of downstream target genes of β-catenin/LEF and c-jun/AP-1.
(A-D) Quantitative analysis of the mRNA level of CD44, c-myc, and Cyclin D1 in A549 (A), H1650 (B), H1975 (C), and H460 (D) cells treated with 5 μM of (+)-usnic acid. Data represent mean ± S.E.M. (standard error of the mean), n = 3. *p<0.05; ***p<0.001; NS, no significant difference when compared to the 0.01% DMSO-treated group in each cell line.