Chinese Herbal Medicine Suppresses Invasion-Promoting Capacity of Cancer-Associated Fibroblasts in Pancreatic Cancer
Figure 5
CXCLs increased the migration and invasion of human pancreatic cancer cells.
Migration and invasion assays were performed on Capan1 cells treated with vehicle, 100/ml CXCL1, 2, and 8, or their antognists 20 µg/ml anti-CXCR1 antibody and 400 nM SB 225002 as indicated, using transwell cell chambers. The number of cells that invaded the membrane was counted in 10 fields under the ×20 objective lens. Original magnification, ×200. The results are presented as the means±SD of values obtained in three independent experiments. The statistical significance was calculated using ANOVA. *P < 0.05.