Multivariable association discovery in population-scale meta-omics studies
Fig 5
Multi-omics associations from the Integrative Human Microbiome Project.
A) Top 10 significant associations (FDR < 0.25) detected by MaAsLin 2’s default linear model (full results in S9–S14 Data). All detected associations are adjusted for subjects and sites as random effects and for other fixed effects metadata including the subject’s age, diagnosis status (CD, UC, or non-IBD), disease activity (defined as median Bray-Curtis dissimilarity from a reference set of non-IBD samples), and antibiotic usage. B,C,D) Representative significant associations with dysbiosis state from each omics profile are shown: species (B), metagenomic (DNA) pathways (C), and metatranscriptomic (RNA) pathways (D). Values are log-transformed relative abundances with half the minimum relative abundance as pseudo count.