Peer Review History

Original SubmissionAugust 5, 2021

Attachments
Attachment
Submitted filename: Response_Letter.docx
Decision Letter - Jian Ma, Editor, Luis Pedro Coelho, Editor

Dear Dr. Huttenhower,

We are pleased to inform you that your manuscript 'Multivariable Association Discovery in Population-scale Meta-omics Studies' has been provisionally accepted for publication in PLOS Computational Biology.

Before your manuscript can be formally accepted you will need to complete some formatting changes, which you will receive in a follow up email. A member of our team will be in touch with a set of requests.

Please note that your manuscript will not be scheduled for publication until you have made the required changes, so a swift response is appreciated.

IMPORTANT: The editorial review process is now complete. PLOS will only permit corrections to spelling, formatting or significant scientific errors from this point onwards. Requests for major changes, or any which affect the scientific understanding of your work, will cause delays to the publication date of your manuscript.

Should you, your institution's press office or the journal office choose to press release your paper, you will automatically be opted out of early publication. We ask that you notify us now if you or your institution is planning to press release the article. All press must be co-ordinated with PLOS.

Thank you again for supporting Open Access publishing; we are looking forward to publishing your work in PLOS Computational Biology. 

Best regards,

Luis Pedro Pedro Coelho

Associate Editor

PLOS Computational Biology

Jian Ma

Deputy Editor

PLOS Computational Biology

***********************************************************

Reviewers #1 and #2 both agreed on the value of the manuscript. Their concerns focused on matters of presentation or acknowledgement of limitations, which the authors have now addressed.

Reviewer #3 raised concerns related to the novelty of the work (which reviewer #2, whilst not questioning the manuscript as a whole, also alludes to in their comment on the comparison with MaAsLin1). However, taking the authors' response into account as well as the fact that the manuscript is now presented as a Software Paper, I feel that there is sufficient novelty to warrant publication. For a long time, users of MaAsLin (of which there are many) were in the awkward position of having to cite a somewhat unrelated paper as a reference as a proper benchmarking of the tool was lacking. Thus, in the absence of reviewer concerns of a technical nature, I believe this paper will fill a gap in the literature.

Formally Accepted
Acceptance Letter - Jian Ma, Editor, Luis Pedro Coelho, Editor

PCOMPBIOL-D-21-01441

Multivariable Association Discovery in Population-scale Meta-omics Studies

Dear Dr Huttenhower,

I am pleased to inform you that your manuscript has been formally accepted for publication in PLOS Computational Biology. Your manuscript is now with our production department and you will be notified of the publication date in due course.

The corresponding author will soon be receiving a typeset proof for review, to ensure errors have not been introduced during production. Please review the PDF proof of your manuscript carefully, as this is the last chance to correct any errors. Please note that major changes, or those which affect the scientific understanding of the work, will likely cause delays to the publication date of your manuscript.

Soon after your final files are uploaded, unless you have opted out, the early version of your manuscript will be published online. The date of the early version will be your article's publication date. The final article will be published to the same URL, and all versions of the paper will be accessible to readers.

Thank you again for supporting PLOS Computational Biology and open-access publishing. We are looking forward to publishing your work!

With kind regards,

Livia Horvath

PLOS Computational Biology | Carlyle House, Carlyle Road, Cambridge CB4 3DN | United Kingdom ploscompbiol@plos.org | Phone +44 (0) 1223-442824 | ploscompbiol.org | @PLOSCompBiol

Open letter on the publication of peer review reports

PLOS recognizes the benefits of transparency in the peer review process. Therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. Reviewers remain anonymous, unless they choose to reveal their names.

We encourage other journals to join us in this initiative. We hope that our action inspires the community, including researchers, research funders, and research institutions, to recognize the benefits of published peer review reports for all parts of the research system.

Learn more at ASAPbio .