Food restriction promotes damage reduction in rat models of type 2 diabetes mellitus
Fig 4
Tolerance to glucose and insulin resistance of rats after food restriction (after 4 months of treatment).
(A) Glucose tolerance test (GTT); (B) Rate of increase of glycemia per minute during GTT; (C) Insulin tolerance test (ITT); (D) Rate of blood glucose reduction per minute during ITT. Groups: control (CC), control with food restriction (CCR), diabetic+streptozotocin+cafeteria-style diet (DEC); diabetic+streptozotocin+cafeteria-style diet with food restriction (DER), diabetic+streptozotocin+nicotinamide (DNC) and diabetic+streptozotocin+nicotinamide with food restriction (DNR). Results expressed as mean±SE (n = 5/group). *a p<0.05 vs CC; b p<0.05 vs DEC; c p<0.05 vs DNC. One-way ANOVA and Tukey’s post-hoc test analysis.