Unique intrahepatic transcriptomics profiles discriminate the clinical phases of a chronic HBV infection
Fig 4
A global module analysis of liver transcriptomics revealed 4 intrinsic functional clusters of HBV clinical phase.
(A) An unsupervised clustering was performed on the relative transcriptional activity of 12 functionally determined modules in the core cohort (n = 52), which generated 2 clusters. The clustering using Euclidean distance and ‘complete’ as linkage for the similarity measurement are shown. (B) An unsupervised clustering was performed on the relative transcriptional activity of 38 functionally undetermined modules in the core cohort (n = 52), which generated 4 intrinsic functional clusters (IFC). The functional enrichment of genes in each IFC was described as the percentage of genes with certain function to the total number of genes in that IFC. The member genes, which differed more than 1.5-fold in expression levels between the IT and one of 3 subsequent phases, are listed in the table on the right-hand site.