Bone Marrow-Specific Knock-In of a Non-Activatable Ikkα Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice
Figure 4
Knock-in of IkkαAA/AA in haematopoietic cells does not influence apoptosis in atherosclerotic lesions.
Analysis of aortic root lesions of Apoe−/− mice transplanted with IkkαAA/AAApoe−/− or Ikkα+/+Apoe−/− BM and receiving a high-fat diet for 13 weeks. (A) Quantification of necrotic cores as percentage of plaque area. (B–C) Quantification of apoptotic cells (Tunel+, B) and apoptotic macrophages (Tunel+Mac2+, C) as percentage of all plaque cells. Graphs represent the mean ± SEM (n = 10–12).