Unique Haploinsufficient Role of the MicroRNA-Processing Molecule Dicer1 in a Murine Colitis-Associated Tumorigenesis Model
Figure 4
Heterozygous mice were more liable to colitis-associated tumors.
a, b, Increased number of tumors in VillinCre-DicerΔ/+ mice. Representative gross colon images are shown in (a). The mean number of tumors per mouse was calculated. Data are presented as means ± s.d. (n = 8 per group) in (b). *, p<0.05. c, The maximum tumor size per mouse was measured. Data are presented as means ± s.d. (n = 8 per group). d, Hematoxylin and eosin staining of colon tumors (upper panels) and immunohistochemical analyses of DICER expression in similar sections of tumors (lower panels) from control and Dicer1-mutant mice after induction of colitis-associated tumors. Scale bars = 200 μm. Representative images are shown from three independent mice per group.