Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete
Figure 4
Comparison of Female and Male Expression of Genes with Higher Female Expression
(A) Female to male expression ratio for 20 genes expressed more highly in females in four human populations. Expression in females is typically 10%–50% higher than in males.
(B) Box and whisker plots showing the median, distribution, and range of expression for females and males for four X chromosome genes with higher female expression. The median is indicated by the red line, the box shows the interquartile range, and the ends of the whiskers the maxima and minima. The y-axis spans a 4-fold range for each graph to enable direct comparison of different genes.
(C) Scatter plot of expression values of four non-dosage compensated genes in 30 males and 30 females from the YRI population. JARID1C is unique as none of the males has higher expression than any of the females. For EIF2S3 the overlap is considerable, as only half the females have higher expression than the highest male and only five males express at a level below the lowest female.