Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation
Fig 4
Mutational signatures and genomic features of mutations in DSBR deficient C. elegans.
A. Mutational signatures of DSBR mutants that exhibited statistically significant different mutation rates to wild-type displayed in numbers of mutations per generation. Bold coloured bars denote individual mutation classes where the number of mutations is different from wild-type, an underscore below each mutation profile indicates mutation types with total mutation numbers different from wild-type, and three stars indicate genotypes which have rates of substitutions, indels or SVs significantly different compared to wild-type (FDR < 5%). B. Estimated composition of structural variants per generation as estimated for wild-type and DNA repair mutants with elevated SV rates. C. Size distributions of tandem duplications (top, pink) and deletions (bottom, green) across wild-type and mutants with elevated SV rates. D. Clustering of mutations in DNA repair deficient mutants. Grey dots reflect the average proportions of clustered mutations. Error bars denote 95% confidence intervals. Mutants with a significantly different propensity for mutation clustering from wild-type (dotted black line) are shown and highlighted in red. ‘Information related to the 528 whole genome sequencing WGS primary-source datasets (56 deposited in this study, 472 deposited in (Suppl Data 1 and Supple Note 1 of [10] can be found in S1 Table).