Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
Fig 4
Analysis of TLR2 and TLR4 surface expression.
Peritoneal macrophages were isolated from WT, conditional gp96-KO, Tlr2-KO and Tlr4-KO mice and the expression of the surface receptors TLR2 and TLR4 was performed by flow cytometry. The histograms are representative for one out of three independent experiments.