Platelet-Derived Growth Factor in the Ovarian Follicle Attracts the Stromal Cells of the Fallopian Tube Fimbriae
Fig 4
Cancer-associated fibroblasts from primary fallopian tube carcinoma undergo chemotaxis to follicular fluid.
(A) Boyden chamber migration assay of CAFs toward control medium and a pool of 4FFs (specimen ID: 10B253, 10B125, 10B005 and 09B334). (B) Chemotactic activities of FTCa1 cells toward PDGF-BB of different concentrations. (C) Levels of estradiol (E2), PDGF-BB, as well as migration cell number of FTCa1cells toward ten different FFs (specimen ID indicated at X-axis). Each datum was obtained from an experiment that was repeated 6 times. ****p< 0.0001.