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A Point-of-Care Immunosensor for Human Chorionic Gonadotropin in Clinical Urine Samples Using a Cuneated Polysilicon Nanogap Lab-on-Chip

Fig 4

SEM, FESEM and AFM morphological analyses of the PSNG electrode.

(a) SEM and FESEM (red box) image of 70 nm gap. (b) SEM and FESEM (red box) image of 60 nm gap (c) SEM and FESEM (red box) image of 25 nm gap (d) FESEM image of hCGab/hCG binding on PSNG electrode surface. (e) AFM images of electrode surface roughness before size expansion (right) and after size expansion (left); a final thickness of less than 100 nm and a bearing ratio of 6.86% were achieved.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0137891.g004