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Concomitant Detection of HER2 Protein and Gene Alterations by Immunohistochemistry (IHC) and Silver Enhanced In Situ Hybridization (SISH) Identifies HER2 Positive Breast Cancer with and without Gene Amplification

Figure 4

Stratification of IHC score 0/1+ tumors and amplification status by SISH to overall survival.

There is a tendency to shorter overall survival in HER2 amplified IHC score 0/1+ cases (Kaplan Meier curves).

Figure 4

doi: https://doi.org/10.1371/journal.pone.0105961.g004