BBA, a Synthetic Derivative of 23-hydroxybutulinic Acid, Reverses Multidrug Resistance by Inhibiting the Efflux Activity of MRP7 (ABCC10)
Figure 4
BBA increases the intracellular accumulation of [3H]-paclitaxel in HEK293/MRP7 cells.
The intracellular accumulation of [3H]-paclitaxel was measured by scintillation counting after cells were pre-incubated with or without BBA or cepharanthine (a known inhibitor of MRP7) for 2 h at 37 °C and then incubated with 0.1 µM [3H]-paclitaxel for another 2 h at 37 °C. Data points represent the means ± SD of triplicate determinations. Experiments were performed at least three independent times. ** P < 0.01, for values versus those in the control group.