CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice
Figure 4
CD4+CD25+FOXP3+ T cells were the functional fraction of Treg cells in the silica-induced lung fibrosis.
Treg cells in HLN (A), spleen (C) and BALF (E) were calculated by flow cytometry. (n = 5) The percentage of CD4+ T cells expressing CD25 and FOXP3 was shown in the graph (B, HLN; D, spleen; F, BALF) (n = 5) (*, as compare with the saline control group, P<0.05; △, as compare with the silica group, P<0.05; #, as compare with 7day of the same group, P<0.05; &, as compare with 28day of the same group, P<0.05).