Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations
Fig 4
Identification of fixed signs.
Cancer-case study. Each column with a number in the top is equivalent to the last column of the table in the panel C (sign) for the glycolysis-case study in Fig 2, for each of the first 20 solved problems of the ensemble of 100 formulated problems. Percentages of negative (% -) and positive (% +) signs refer to the solved problems. The average % gain for all variables and the 100 formulated problems was 29%. In orange, signs dependent on the constraint in Eq (14) that assumes a coordinated regulation changing in parallel the individual activities of Glc transp, HK, PFK, and ENO. See Fig 5 for a numerical summary of the final domains. See Material and Methods for a supplementary description of the network and abbreviations.