Human Muse cells reduce myocardial infarct size and improve cardiac function without causing arrythmias in a swine model of acute myocardial infarction
Fig 3
Differentiation of Muse cells into vessels.
A: GFP-labelled Muse cells and CD31-positive microvessels in the infarct border area. GFP (green) and CD31 (Red) are merged, suggesting that GFP-labelled Muse cells differentiated into vascular endothelium. Bar = 50 μm. B: Negative control in the infarct border area. CD31 (red), DAPI (blue), Bar = 25 μm. C: Typical pictures of CD31-positive microvessels by immunohistological staining in the Vehicle and Muse groups. Bars = 50 μm. D: The number of CD31-positive microvessels by immunohistological staining is significantly greater in the Muse (n = 5) group than in the Vehicle (n = 7) group.