N-Acetyl-L-Leucine Accelerates Vestibular Compensation after Unilateral Labyrinthectomy by Action in the Cerebellum and Thalamus
Fig 3
Dose-dependent effects of N-acetyl-L-leucine on postural compensation after unilateral labyrinthectomy.
Sham treatment (vehicle) and N-acetyl-L-leucine (3.75, 15 or 60 mg/kg) was administered i.v. on days 1, 2 and 3 (six animals per group). Postural imbalance scores were analyzed in all groups on days 1, 3, 7 and 15. Postural imbalance was significantly decreased in the 60 mg/kg (p<0.004) but not in the 15 mg/kg or 3.75 mg/kg group. Values are depicted as mean, the standard deviation as error bars. Significant values (60 mg/kg vs. vehicle and 60 mg/kg vs. 3.75mg at day 7) are marked with an asterisk.