Mannan-Binding Lectin Inhibits Candida albicans-Induced Cellular Responses in PMA-Activated THP-1 Cells through Toll-Like Receptor 2 and Toll-Like Receptor 4
Figure 3
MBL inhibits C. albicans-induced IL-8 and TNF-α productions from PMA-activated THP-1 cells.
PMA-activated THP-1 cells were stimulated with HK Y or H cells of C. albicans at a Candida/THP-1 ratio of 2:1 in the presence of the indicated concentrations of MBL, anti-MBL pAb and MBL, or HSA for 24 h. Supernatants were harvested and subjected to ELISA for IL-8 (A) and TNF-α (B). The data are expressed as mean ± SD of four independent experiments. *P<0.05 as compared to C. albicans-stimulated group. Similar results were observed in four independent experiments.