Adverse prognosis of glioblastoma contacting the subventricular zone: Biological correlates
Fig 3
SVZ involvement in glioblastoma correlates with increased protein expression of key markers of (epithelial-)mesenchymal transformation.
Increased protein expression levels of (epithelial-)mesenchymal transformation markers C/EBP-β (Mann Whitney U test, P = 0.029) and PY705-STAT3 (Mann Whitney U test, P = 0.002), but not PS536-p65, were observed in glioblastomas contacting the SVZ. No expression differences in stem cell markers CD133 or GFAP-δ were observed between tumors with or without SVZ contact.