Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats
Fig 3
Skeletal phenotypes of CNP-KO and WT rats and the effect of CNP-53 on bone length.
(A) Soft x-ray images of 8-week-old CNP-KO and WT rats. (B), (C) Bone lengths (B) and especially those in the paw (C) of rats at the age of 8 weeks as measured from soft x-ray films. The bars indicate the mean + SE. Open bars, vehicle (n = 5 in the both genotypes); closed bars, CNP-53 (0.5 mg/kg/day, n = 6 in the both genotypes). KO, CNP-KO rats; WT, WT rats. *, p < 0.05 vs. WT rats that received vehicle group. **, p < 0.01 vs. WT rats that received vehicle group. ##, p < 0.01 vs. KO rats that received vehicle group, based on the Student’s t-test.