Corticosteroids Augment BRAF Inhibitor Vemurafenib Induced Lymphopenia and Risk of Infection
Fig 3
Distribution and degree of lymphopenia in treatment groups.
Shown are the frequency and grade of lymphopenias in patients receiving BRAF inhibitor (vemurafenib or dabrafenib) monotherapy or those receiving both BRAF inhibitor and dexamethasone. VEM- vemurafenib; DAB- dabrafenib; DEX- dexamethasone; delta lymphocytes- difference between pretherapeutic lymphocyte count and lymphocyte count under therapy; CTCAE = Common Terminology Criteria of Adverse Events, version 4.0; corresponding symbols indicate statistically significant difference between groups (p < 0.05).