A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum
Figure 3
Hypothetical model for the biosynthesis of compound 1 in P. chrysogenum and A. niger by the HcpA NRPS.
A: Binding of the monomers on the carrier protein domains. Both isolated condensation and thiolation domains C4 and T4, missing a preceding adenylation domain, are assumed to correspond to the adenylation domain A4, located upstream. B: Proposed assembly of compound 1 including condensation domains presumed for catalyzing the formation of the peptide bond.