Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Fig 3
Polygenic hazard score validation in ADGC Phase 2 cohort.
(A) Risk stratification in ADGC Phase 2 cohort, using PHSs derived from ADGC Phase 1 dataset. The dashed lines and shaded regions represent Kaplan–Meier estimations with 95% confidence intervals. (B) Predicted age of AD onset as a function of empirical age of AD onset among cases in ADGC Phase 2 cohort. Prediction is based on the final survival model trained in the ADGC Phase 1 dataset. AD, Alzheimer disease; ADGC, Alzheimer’s Disease Genetics Consortium; PHS, polygenic hazard score.