Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy
Fig 2
DAA therapy induces rapid suppression of some but not all antiviral signaling molecules.
Kinetic analysis of transcriptional levels of CXCL10 (black), CXCL11 (purple), RIG-I (yellow), IRF3 (blue), IFIT1(ISG56) (red), IFITM1 (grey), USP18 (green), IL1β (black circles, dotted line) and plasma viral load (black crosses with black dashed line) from PBMCs in DAA patient cohort 2 (n = 11).