Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi
Fig 2
Effect of mitochondrial respiration inhibitors on azole resistance.
Itraconazole resistance is shown as IC50ITRA of fungi grown on sub-inhibitory concentrations of respiratory inhibitors. Results represent averages of three biological replicates with three technical replicates for each. Error bars represent standard deviation. C: control consisting of addition of water, DMSO or acetone to the medium. Only the water control is shown here for simplicity as all solvent controls showed indistinguishable growth rates. R: Rotenone, P: piericidin A, Az: sodium azide As: azoxystrobin, An: antimycin A, CN: potassium cyanide Ol: oligomycin. Error bars represent standard deviation of IC50 values.