Nitrative Stress Participates in Endothelial Progenitor Cell Injury in Hyperhomocysteinemia
Fig 2
Endothelium-dependent vasorelaxation and morphology change of thoracic aorta.
Both endothelium-dependent vasorelaxation and morphology of thoracic aorta were measured in hyperhomocysteinemia rats, and anti-peroxynitrite treatment significantly alleviated endothelial injury induced by hyperhomocysteinemia. (A) ACh-induced endothelium-dependent vasorelaxation. Data were expressed as mean±SD; n = 6–10. Differences between the groups were assessed by repeated measures ANOVA followed by Bonferroni post hoc test. **P<0.01 versus Control; ##P<0.01 versus HHcy. (B) HE staining. Bar represented 50 μm; (C) Scanning electron microscopic observation of thoracic aortas in which the arrows showed the damaged endothelial cells and fibrin-like material. Bar represented 50/10 μm.