Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats
Fig 2
Iron deficiency increases TMPRSS6 protein content.
(A) Increase of TMPRSS6 protein content in rats and mice kept on an iron-deficient diet. Control animals (C) were fed standard laboratory diet, iron-deficient animals (ID) were fed an iron-deficient diet since weaning. Arrows denote TMPRSS6-specific bands, arrowhead denotes a non-specific band present in rat liver samples. ATP1A is used as loading control. (B) TMPRSS6 band density quantifications. n = 4, asterisk denotes statistical significance (p<0.05). (C) Effect of iron deficiency anemia on liver Tmprss6 mRNA content. Tmprss6 mRNA content is determined relative to Actb mRNA.