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Impact of Chemotherapy Delay on Overall Survival for AML with IDH1/2 Mutations: A Study in Adult Chinese Patients

Fig 2

The plots illustrating the interaction between IDH1/2 mutations status and TDT.

Log hazard in mortality for AML patients by IDH1/2 mutation status (A), and estimated difference of log hazard in mortality between IDH1/2 mutations and wildtype together with its 95% confidence band (B). Figure C shows that for patients with IDH1/2 wildtype the survival rates decrease in a similar fashion, whereas Figure D shows IDH1/2 mutant patients with a TDT of 7 days or more have a lower survival rate. MFPIgen function (A) and MFPI function (B) were respectively estimated the interaction effects. Kaplan–Meier survival curves (C and D) illustrating the interaction between TDT and IDH1/2 mutations.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0140622.g002