Interferon Beta and Vitamin D Synergize to Induce Immunoregulatory Receptors on Peripheral Blood Monocytes of Multiple Sclerosis Patients
Figure 2
Effects of 1α,25 Dihydroxyvitamin D3 in combination with IFN beta on monocytic ILT3 and ILT4 expression.
PBMC derived from RRMS patients (n = 9) were stimulated with 1α,25 Dihydroxyvitamin D3 (100 nM) and/or IFN beta (1000 IE) over a 48 h period. ILT3 and ILT4 protein expression on CD14+ cells was assessed by flow cytometry. The fold induction is shown (mean + SEM). A repeated measurement ANOVA with Bonferroni multiple comparison test was performed to assess statistical significance (* p<0,05; **p<0.005).