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Characterizing the Network of Drugs and Their Affected Metabolic Subpathways

Figure 2

The DRSN network.

The circles and rectangles in the network correspond to drugs and metabolic subpathways, respectively. A drug and a metabolic subpathway are connected by an edge if the corresponding drug-affected genes are statistically significantly enriched to the corresponding subpathway. Node size is proportional to the degree of the node. Nodes are colored according to 14 ATC and 11 KEGG pathway categories.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0047326.g002