Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans
Figure 2
Differential feeding behavior of Nbea+/− and WT mice.
Male mice were tested at the age of 8–10 weeks, prior to the manifestation of a significant body weight difference between the genotypes. Compared to WT mice, Nbea+/− mice (A) ate more ad libitum of the energy-dense and palatable high-fat high-sugar (HFHS) solid diet; (B) ate more standard chow upon 2-h refeeding after overnight food deprivation; (C) consumed more of the caloric and palatable 4.1% Intralipid, 10% sucrose, 10% glucose and 10% fructose solutions; but (D) they consumed the same amounts of tastants which do not contain calories, i.e. saline, 0.1% saccharin or 0.05% sucralose, despite their palatability. Nbea+/− mice (E) were not resistant to leptin, but they were (F) more sensitive to the anorexigenic naltrexone (NTX) than their WT counterparts. *, P<0.05; **, P<0.01; ***, P<0.001; error bars, ± SEM.