NCX1 represents an ionic Na+ sensing mechanism in macrophages
Fig 2
NCX inhibitors abrogate HS-boosted NO production of LPS-stimulated MΦs.
Lower panel: nitrite levels of RAW264.7 MΦs pretreated with indicated inhibitors and stimulated ± LPS ± HS or 80 mM urea (mean ± SD; n = 9; Student t test or Mann–Whitney test; *p < 0.05). Upper panel: changes of means in nitrite production upon indicated stimulation and/or treatment (Δ nitrite). For numerical raw data, please see S1 Data. HS, high salt; LPS, lipopolysaccharide; MΦ, monocyte/macrophage-like cell; NCX, Na+/Ca2+ exchanger; NO, nitric oxide; NS, normal salt; n.s., not significant.