Manipulating the revision of reward value during the intertrial interval increases sign tracking and dopamine release
Fig 2
DA release to the CS and US is stronger during sessions with 120-s ITIs.
(A-B) Average DA release over time for 120-s (red) and 60-s (blue) ITI groups sessions. “A” represents DA release averaged within the session first and then across sessions, whereas DA release in “B” represents averages taken within each session and rat, and then averaged across rats. Error bars represent SEM, with “n” being session and rat for “A” and “B,” respectively. (C-D) Average DA release during the US period (y-axis) relative to time the photobeam in the food cup was broken during the ITI for the 120-s (red) and 60-s (blue) ITI groups for each session. (E-F) Average DA release during the CS period (y-axis) relative to time the photobeam in the food cup was broken during the ITI for the 120-s (red) and 60-s (blue) ITI groups. Underlying data for Fig 2 can be found in S2 Data. CS, conditioned stimulus; DA, dopamine; ITI, intertrial interval; US, unconditioned stimulus.