Perturbation of BRMS1 interactome reveals pathways that impact metastasis
Fig 2
BRMS1 interacts with SIN3/HDAC members alternatively based protein domain.
(A) Likelihood of binding for each SIN3A member was evaluation based on TopS score for each of the BRMS1 mutants. Cluster is based upon Euclidean distance. (B) Crosslink map for the BRMS1 protein, data is extracted from SIN3A XL-MS experiments from Adams et al [24]. (C) SIN3A co-immunoprecipitation of nuclear lysates followed by MALDI-TOF mass spectrometry. (D) Utilizing MS results from Adams et al [24] dNSAF for SIN3A and SIN3B in relation to BRMS1 and BRMS1L.