Interaction between BDNF val66met polymorphism and personality on long-term cardiac outcomes in patients with acute coronary syndrome
Fig 2
Associations of personality cluster with cumulative incidence (%) of composite major adverse cardiac events (MACE) by brain derived neurotrophic factor (BDNF) val66met polymorphism.
Hazard ratios (95% confidence intervals) [HR (95% CI)] using Cox proportional hazards models were calculated after adjustment for age, gender, education, accommodation, Beck Depression Inventory scores, previous history of depression, hypertension, diabetes, hypercholesterolemia, obesity, smoking, past history of ACS, ACS diagnosis, Killip class, left ventricular ejection fraction, and serum levels on troponin I, creatine kinase-MB, and high sensitivity C-reactive protein at baseline. Multiplicative interaction terms between personality cluster and BDNF val66met polymorphism on composite MACE were statistically significant (P-value = 0.001). Figure a) denotes the association between personality cluster and composite MACE in all participants, and other Figures denote those by BDNF polymorphism: b) val/val, c) val/met, and d) met/met genotypes.