Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa
Figure 2
IFN-γ secretion in response to secreted, latent, and reactivation Mtb antigens in active TB and LTBI subjects, from five African sites.
IFN-γ ELISA was performed on supernatants collected after 7-day antigen stimulation of diluted blood from TB cases (grey) and TST+ (LTBI) controls (white) from five sites in Africa. Line indicates median, whiskers indicate 5–95% range and dots indicate outliers. Data were analysed by Mann-Whitney U-test within sites for HIV– and/or HIV+ subjects. Significant differences are indicated: *=p<0.05; **=p<0.01; ***=P<0.001.