Peer Review History
Original SubmissionMarch 30, 2020 |
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PONE-D-20-09119 Keratoplasty in China: a 5-year review from 2014 to 2018 PLOS ONE Dear Dr. Shi, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but some points have to be addressed before it can be considered further. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. We would appreciate receiving your revised manuscript by Jul 02 2020 11:59PM. When you are ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. To enhance the reproducibility of your results, we recommend that if applicable you deposit your laboratory protocols in protocols.io, where a protocol can be assigned its own identifier (DOI) such that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols Please include the following items when submitting your revised manuscript:
Please note while forming your response, if your article is accepted, you may have the opportunity to make the peer review history publicly available. The record will include editor decision letters (with reviews) and your responses to reviewer comments. If eligible, we will contact you to opt in or out. We look forward to receiving your revised manuscript. Kind regards, Yu-Chi Liu, M.D Academic Editor PLOS ONE Journal Requirements: When submitting your revision, we need you to address these additional requirements. 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf 2. Please include additional information regarding the survey or questionnaire used in the study and ensure that you have provided sufficient details that others could replicate the analyses. For instance, if you developed a questionnaire as part of this study and it is not under a copyright more restrictive than CC-BY, please include a copy, in both the original language and English, as Supporting Information. 3. Please modify the title to ensure that it is meeting PLOS’ guidelines (https://journals.plos.org/plosone/s/submission-guidelines#loc-title). In particular, the title should be "specific, descriptive, concise, and comprehensible to readers outside the field" and in this case it is not informative and specific about your study's scope and methodology. 4. PLOS requires an ORCID iD for the corresponding author in Editorial Manager on papers submitted after December 6th, 2016. Please ensure that you have an ORCID iD and that it is validated in Editorial Manager. 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Please amend the manuscript submission data (via Edit Submission) to include authors: Ting Huang2,3, Zhiqiang Pan2,4, Jie Wu2,5, Jianjiang Xu2,6, Jing Hong2,7, Wei Chen,2,8, Huping Wu9, Qian Kang10, Lei Zhu2,11, Lingling Fu12, Liqiang Wang2,13, Guigang Li2,14, Zhihong Deng15, Hong Zhang2,16, Hui Xu17, Qingliang Zhao18, Hongshan Liu19, Linnong Wang2,20, Baihua Chen2,21, Xiuming Jin2,22, Minghai Huang23, Jizhong Yang24, Minghong Gao2,25, Wentian Zhou26, Hanping Xie2,27, Yao Fu2,28, Feng Wen29, Changbo Fu30, Shaozhen Zhao2,31, Yanning Yang2,32, Yanjiang Fu33, Tao Yao34, Chaoqing Wang35, Xiaonan Sun36, Xiaowei Gao2,37, Maimaitiming Reziwan38, Yingping Deng2,39, Jian Li40, Limei Liu 41, Bo Zeng42, Lianyun Bao43, Hua Wang 2,44, Lijun Zhang2,45, Zhiyuan Li46, Zhijian Yin47, Yuechun Wen 48, Xiao Zheng 49, Liqun Du 50, Zhenping Huang 51, Xunlun Sheng 52, Hui Zhang2,53, Lizhong Chen 54, Xiaoming Yan 2,55, Xiaowei Liu 56, Wenhui Liu 57, Yuan Liu 58, Liang Liang 59, Pengcheng Wu 60, Lijun Qu61, Jinkui Cheng62, Hua Zhang63, Qige Qi64, Yangkyi Tseten65, Jianping Ji3, Jin Yuan2, 3, Ying Jie4, Jun Xiang6, Yifei Huang2,13, Yuli Yang2,27, Ying Li2,56, Yiyi Hou1, Tong Liu1, Lixin Xie. 6. Please include captions for your Supporting Information files at the end of your manuscript, and update any in-text citations to match accordingly. Please see our Supporting Information guidelines for more information: http://journals.plos.org/plosone/s/supporting-information. Additional Editor Comments (if provided): [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Yes Reviewer #2: Yes Reviewer #3: Yes ********** 2. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: N/A Reviewer #3: N/A ********** 3. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: No Reviewer #2: Yes Reviewer #3: Yes ********** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: No Reviewer #3: Yes ********** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: This is a very extensive study with valuable information. The paper is well written. I have the following comments/suggestions to improve the scientific content. The information of donor cornea preservation is incomplete. The authors should elaborate this aspect by providing specific information about the type of corneal storage medium and describe what is meant by the dry method. The survey was based on a questionnaire. More details of the methodology of obtaining the information and the questions asked and collection of the responses can be provided. Reviewer #2: Thank you for the opportunity to review this manuscript. It has the potential to be an important paper, as this is the first time such a comprehensive survey of keratoplasty in China has been attempted. The current paper is a good draft, but I think there are multiple clarifications that need to be made before it can be published. Background 1) many readers outside of China will not be familiar with the geography and the classification of provinces in China, so may I suggest that you explain - how provinces and cities in China are categorised into "tiers" - if possible, a map to show where the various participating hospitals are located - you may not be able to place all 64 hospitals on the map, but perhaps you can list the hospitals by geographical location? Methods 2) Some detail needs to be provided on how corneas in China are obtained. - I understand that use of foreign or imported tissue is highly restricted? - the use of bio-engineered tissue is very interested, could you elaborate on how these tissues are engineered? - proportion of fresh, versus frozen, versus bio-engineered tissue would give readers some context 3) a copy of the questionnaire used will be important, and included as an annex. An English translation would be appropriate for most readers. 4) Was there also information collected on graft survival, at least in the first year? 5) Information on the number of surgeries done - lines 276 to 296 - is best summarised in a table rather than written in the text. Similarly with the gender and age distribution. 6) Indications for surgery - unfortunately, cornea leukoma is a rather rather term, unless there is a specific-definition used by the Chinese Cornea Society? Usually there is an underlying cause - congenital, trauma, infection. Would the authors be able to give further details? - similarly, cornea perforation is very common, but it would be better to further tell readers if this is due to trauma or infection, ot other causes - I am surprised bacteria keratitis is such a common indication, but fungal keratitis is not, even though fungal infections are as high as bacterial keratitis in China. Is this practice pattern (meaning that surgery is not done for fungal keratitis), or is it because it is classified under other indications - eg perforations? 7) ALK indications - curious to see small numbers of corneal perforation - are these patch grafts? - similarly I see ALK for pseuophakic bullous keratopathy 8) Discussion - Could the authors comment how the availability of tissue also affects practice patterns? for example, there could be much more ALK done in China vs the USA because of the lack of healthy fresh tissue for PK and EK - could authors also comment on what more can be done to improve the CT situation - what this paper shows is that much more CT needs to be done to have any hope of helping the 3 million in China with cornea blindness - is bioengineered cornea a good option? what about training and facilities - 64 hospitals perform transplants, but many are done in smaller units and do much fewer transplants than the top 5 hospitals Reviewer #3: This paper aims to analyze the trend of corneal transplants in China, focusing in particular on the diffusion of lamellar techniques and surgical indications and to compare the results with the trend in United States (US). I found the manuscript interesting and original, since few data are available about corneal transplant in China. I suggests the authors to include the survey as supplemental material. Moreover, I suggest to include in the discussion the results of similar studies conducted in other countries, in addiction to the US situation. The sentence at page 21 ,lines 377-328, should be corrected, since only EK surpassed the number of PK in US since 2011 (ALK is still inferior to PK). ********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: Yes: Dr Radhika Tandon, MD, FRCOphth, FRCSEd; Professor of Ophthalmology, Co-Chairperson National Eye Bank, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Also immediate past president Eye Bank Association of India (EBAI) and immediate past Vice President Association of Eye Banks of Asia (AEBA). Reviewer #2: No Reviewer #3: No [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files to be viewed.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email us at figures@plos.org. Please note that Supporting Information files do not need this step. |
Revision 1 |
PONE-D-20-09119R1 Survey report on keratoplasty in China: a 5-year review from 2014 to 2018 PLOS ONE Dear Dr. Shi, Thank you for submitting your manuscript to PLOS ONE. The reviewers have raised some comments and we would like to invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Please submit your revised manuscript by Sep 17 2020 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols We look forward to receiving your revised manuscript. Kind regards, Yu-Chi Liu, M.D Academic Editor PLOS ONE [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #1: All comments have been addressed Reviewer #2: (No Response) Reviewer #3: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: (No Response) Reviewer #2: Yes Reviewer #3: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: (No Response) Reviewer #2: Yes Reviewer #3: N/A ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: (No Response) Reviewer #2: Yes Reviewer #3: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: (No Response) Reviewer #2: No Reviewer #3: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: The authors have addressed the concerns raised. Minor editorial corrections and language changes are required. For example one-center can be changed to single center. Line 468-471 the sentence "Overall, in China, the geographical ...weak in CT" in the conclusion needs to be re-written as it is not clear. Reviewer #2: Thank you once again for the opportunity to review this paper, as I was Reviewer 2 for the first submission. I appreciate that the authors have made some of the amendments as I have suggested, including summarising the data in tables. Other information that I felt would have made this a more complete paper appears to not be available, based on the methods and on how the questionnaire was designed. I think it is therefore important to include a section of the paper to address the limitations of the study - namely that this was a retrospective study where information is incomplete, diagnoses and classification of indications are not standardised (eg the meaning of cornea leukoma), and that outcome data in terms of graft survival was not obtained. Reviewer #3: (No Response) ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: No Reviewer #3: No [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step. |
Revision 2 |
Survey report on keratoplasty in China: a 5-year review from 2014 to 2018 PONE-D-20-09119R2 Dear Dr. Shi, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Yu-Chi Liu, M.D Academic Editor PLOS ONE Additional Editor Comments (optional): Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #2: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #2: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #2: Yes ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #2: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #2: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #2: (No Response) ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #2: No |
Formally Accepted |
PONE-D-20-09119R2 Survey report on keratoplasty in China: a 5-year review from 2014 to 2018 Dear Dr. Shi: I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org. If we can help with anything else, please email us at plosone@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Dr. Yu-Chi Liu Academic Editor PLOS ONE |
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