Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration
Fig 10
Integration site profiles of WT and Gag iSTP mutant viruses.
(A) Percent of WT (gray bar), S224A (backslash), and T225A (horizontal slash) integrations within RefSeq genes. An independent HIV-1 dataset (black) [85] was included for comparison. (B) Percent of integrations within lamina-associated domains (LADs). (C) Average gene density in 1 Mb regions surrounding the integration sites. The data from three wt and two S224A and T225A integration site libraries (Table 1) were combined, with error bars indicating the resulting standard deviation. Dotted, horizontal lines represent the percent of integrations from the in vitro integration dataset. Please refer to S7 Fig for statistical analyses.