Comparison of efficacy of SHENQI compound and rosiglitazone in the treatment of diabetic vasculopathy analyzing multi-factor mediated disease-causing modules
Fig 1
Pathological morphology comparison.
(A) Images of abdominal aortic intima pathology in healthy C57BL/6J mice. The vascular endothelial cells are flat and closely attached to the flat inner elastic plate. The medium elastic plate and the vascular smooth muscle cells are arranged in parallel and the inner membrane is smooth and tidy. (B) KKAy Pathological section imaging of vascular endothelial cells in spontaneous diabetic mice. The vascular endothelial cells showed swelling and no obvious endothelial cell shedding. (C) Pathological section imaging of abdominal aortic endothelial cells in diabetic macroangiopathy group. The abdominal aortic endothelial cells showed high edema, large area and continuous flaking, and the intima was not smooth. (D) Pathological section imaging of abdominal aortic endothelial cells in mice in the rosiglitazone group. It appears to be scattered in focal endothelial cells with mild edema. (E) Pathological section imaging of abdominal aortic endothelial cells in the SHENQI compound group. Occasionally, it is spotted and accompanied by mild edema. (F) Images of pathological sections of abdominal aortic endothelial cells in mice of yangyinyiqi group. (G) Pathological section imaging of abdominal aortic endothelial cells in mice of huoxue group. The vascular endothelial cells of the yangyinyiqi group and the huoxue group showed cell shedding and edema, which was lighter than that of the diabetic group and more severe than the SHENQI compound group.