Co-Circulation and Genomic Recombination of Coxsackievirus A16 and Enterovirus 71 during a Large Outbreak of Hand, Foot, and Mouth Disease in Central China
Figure 1
Monthly distributions of patients with HFMD and viral infection in Central China.
During April 2011 to March 2012, a total of 1844 HFMD patients from Central China were hospitalized at Wuhan Medical Treatment Center and enrolled in this study. Throat swabs from each of the patients were collected and subjected to RNA extraction and RT-PCR detection using three sets of primers specifically amplify a universal sequence commonly presented in all human enteroviruses, and the specific sequences of EV71, and CVA16, respectively. Among them, 422 were infected with CVA16, 334 were infected with EV71, 38 were co-infected with EV71 and CVA16, and 35 were infected with other enteroviruses. Monthly distribution of the 1844 patients with HFMD, including the 422 patients infected with CVA16, the 334 patients infected with EV71 (EV71), and the 38 patients co-infected with EV71 and CVA16, were described.