Transcriptional Regulation of an Insulin-Sensitizing Adipokine Adipolin/CTRP12 in Adipocytes by Krüppel-Like Factor 15
Figure 1
KLF9 and KLF15 are down-regulated in adipose tissue of obese mice and TNFα-treated cultured adipocytes.
Quantitative RT-PCR method was used for measurement of mRNA levels. A, mRNA levels of KLF3, KLF9, KLF10, KLF13, KLF15 and adipolin (APL) in adipose tissues of control lean and high fat diet-induced obese (DIO) mice. N = 3–4 in each group. B, mRNA levels of KLF3, KLF9, KLF10, KLF13, KLF15 and adipolin (APL) in 3T3-L1 adipocytes. 3T3-L1 adipocytes were treated with TNF-α (10 ng/ml) or vehicle for 24 h. N = 3 in each group.